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KMID : 0371320070730050392
Journal of the Korean Surgical Society
2007 Volume.73 No. 5 p.392 ~ p.399
Relation of the E-cadherin Expression and the Lauren Classification in Stomach Cancer according to the Tumor Location
Jun Kyong-Hwa

Won Yong-Sung
Na Gun-Hyung
Suh Young-Jin
Cho Hyun-Min
Park Woo-Bae
Chin Hyung-Min
Chun Chung-Soo
Abstract
Purpose: E-cadherin (ECD) plays a pivotal role in integrating the normal tissue architecture and the suppression of cancer invasion, including stomach cancer. The epidemiology of stomach cancers is noticeably different according to the site of the index tumor, even though the stomach cancers all have similar gross shapes. In this study, the relation between the expression of ECD, along with the clinicopathologic parameters and recurrence or survival, were investigated for patients with gastric adenocarcinoma according to the tumor location.

Methods: We examined formalin-fixed, paraffin-embedded archival tissues from 50 surgically resectable gastric adenocarcinomas, which were grouped by the index tumor site as follows: distal (antrum) versus proximal (mid and upper body). To elucidate the correlation between the ECD expression and the site of the stomach cancer with the other clinicopathologic factors, we examined the ECD tissue status via performing immunohistochemistry. To compare the rates of recurrence and survival among subgroups, the patients were followed up for an average of 42 months.

Results: Among the 50 tumors examined, 28 (56%) tumors showed various degrees of a ECD expression. The gender, age, size, depth of invasion, lymph node metastasis, stage, lymphatic invasion and vascular invasion were not related with the ECD expression. The Lauren classification was cor- related with the ECD expression in the mid and upper body stomach cancer, but not in the antral stomach cancer (P=0.042). The expression of ECD was not related with the survival rate (P=0.223). There was no significant difference in the recurrence rate between the subgroups with and without an abnormal expression of ECD (P=0.588).

Conclusion: For the mid and upper body stomach cancer, the expression of E-cadherin correlated with the diffuse type of cancer, according to the Lauren classification, but not with the survival rate. (J Korean Surg Soc 2007;73:392-399)
KEYWORD
Stomach cancer, E-cadherin, Lauren classification
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